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pentobarbital increases toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. CYP3A4 inducers may possibly raise the metabolism of ifosfamide to its Energetic alkylating metabolites.pentobarbital will reduce the level or effect of norgestrel by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Mo

pentobarbital will reduce the extent or outcome of phenytoin by impacting hepatic enzyme CYP2C9/ten metabolism. Use Warning/Keep an eye on.Phenobarbital appears to interfere with the absorption of orally administered griseofulvin, As a result reducing its blood stage.Information in rodents As well as in primates propose that the neuronal and oligod